Anti-GABARAPL2 Antibody

Product Name

Anti-GABARAPL2 Antibody

View all GATE-16/GABARAPL2 Antibodies

SKU/Catalog Number

A01927-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-GABARAPL2 Antibody (Catalog # A01927-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

GABARAPL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-GABARAPL2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01927-1)

Host

Rabbit

Contents

GABARAPL2 antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

Clone: SK7

Isotype

IgG

Immunogen

GABARAPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human GABARAPL2. The immunogen is located within the last 50 amino acids of GABARAPL2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

GABARAPL2 antibody is human, mouse and rat reactive. Multiple isoforms of GABARAPL2 are known to exist.

Reactive Species

A01927-1 is reactive to GABARAPL2 in Human, Mouse, Rat

Applications

A01927-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

13.667kDa

Background of GATE-16/GABARAPL2

Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system (1). It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2). GABARAPL2 (GABAA receptor-associated protein-like 2), also known as GATE16, was initially identified as a membrane transport modulator and is a mammalian ortholog to the autophagy protein ATG8 (3,4). It is thought that GABARAPL2 and other members of the ATG8 family act as scaffolds for assembly of the Unc-51 like kinase (ULK) complex in the formation of autophagosomes (5).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

GABARAPL2 antibody can be used for detection of GABARAPL2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of GABARAPL2 in human brain tissue lysate with GABARAPL2 antibody at (A) 1 and (B) 2 μg/ml.

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Immunohistochemistry of GABARAPL2 in rat brain tissue with GABARAPL2 antibody at 5 μg/mL.

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Immunofluorescence of GABARAPL2 in rat brain tissue with GABARAPL2 antibody at 20 μg/mL.

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Immunohistochemistry of GABARAPL2 in mouse brain tissue with GABARAPL2 Antibody at 5 μg/mL.

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Immunofluorescence of GABARAPL2 in mouse brain tissue with GABARAPL2 Antibody at 20 μg/mL.

Green: GABARAPL2 Antibody (A01927-1)
Blue: DAPI staining

Gene/Protein Information For GABARAPL2 (Source: Uniprot.org, NCBI)

Alternative Names

Apg8p2; ATG8; ATG8C; FLC3A; GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2; Ganglioside expression factor 2; GATE16; GATE-16; GEF2; GEF-2; GEF2GEF-2; General Protein Transport Factor P16; Golgi-Associated ATPase Enhancer Of 16 KDa; MAP1 light chain 3 related protein; MAP1 light chain 3-related protein GABARAPL2 ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2 GABA type A receptor associated protein like 2 gamma-aminobutyric acid receptor-associated protein-like 2|GABA(A) receptor-associated protein-like 2|MAP1 light chain 3 related protein|ganglioside expression factor 2|general protein transport factor p16|golgi-associated ATPase enhancer of 16 kDa

For more info on GABARAPL2, check out the GABARAPL2 Infographic

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In this infographic, you will see the following information for GABARAPL2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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